A group of scientists from the Laboratory of Structural Biology at the International Institute of Molecular and Cell Biology conducted a study on DNA methyltransferases, the results of which were published in the journal “Nucleic Acids Research”.
It was widely believed that inhibitor complexes with halogen compounds were irreversible, but it was discovered that in the presence of small chemicals normally used in methyltransferase work, compounds with a halogen atom at the site that should be methylated initially inhibit the enzyme. It turned out that over time they are converted similarly to normal cytosine.
Extremely meticulous research to understand and document these mechanisms took the scientists a decade and their findings may contribute to understanding the interaction of methyltransferases with compounds used in the treatment of many diseases, including AML and CMML leukemias.
We are proud that the DNA oligonucleotides we synthesized contributed to making this discovery. We would like to congratulate all the scientists involved in this endeavor on their success and wish them more success in their scientific careers.
We would also hereby like to invite you to read the aforementioned publication, as well as the article treating the publication itself, on biotechnologia.pl, which can be accessed via the links below.
If you are looking for a similar solution in your research work, please contact us via our contact form or send us an email.
